eyeIntegration
Resources and Data
The human eye has several specialized tissues which direct, capture, and pre-process information to provide vision. In order to profile specific eye tissues, researchers have widely used RNA-seq gene expression analyses. They've used it in large consortium studies - like the GTEx project - to study tissue-specific gene expression patterning. However, there hasn't been an integrated study of multiple eye tissues expression patterning with other human body tissues. That's why NEI has collated publicly available healthy human RNA-seq datasets and a substantial subset of the GTEx project RNA-seq datasets - and processed all of them in a consistent bioinformatic workflow. We used this fully integrated dataset to probe the relatedness and biological processes between the cornea, retina, RPE (choroid), and the rest of the human tissues with differential expression, clustering, and GO term enrichment tools. We also leveraged our large collection of retina and RPE tissues to build the first human weighted gene correlation networks and use them to highlight known biological pathways and eye gene disease enrichment.
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eyeIntegration Dataset
Probe the relatedness and biological processes between the cornea, retina, RPE (choroid), and the rest of the human tissues by using a fully integrated dataset with differential expression, clustering, and GO term enrichment tools.