Ocular Proteome
Resources and Data
Evaluate mutation severity using protein structures that are from protein databases or generated by homology modeling, refined by molecular dynamics, and mutated using global computational mutagenesis.
Protein atomic structures from inherited eye disease were obtained by molecular modeling and/or from publicly available database of protein crystal structures. The stability of each protein molecule was evaluated from atomic level of protein structure and global landscape of possible protein stability changes was generated for any missense mutation. The method was created for the express analysis of the genetic disease phenotype changes.
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Ocular Proteome Dataset and Tool
NEI has made the Ocular Proteome dataset available so that researchers can analyze protein changes related to genetic eye diseases. The dataset holds structures for over 100 proteins and over 1 million variants, cataloging the proteins atomic structures and stability generated by global computational mutagenesis.
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Molecular Dynamics Trajectories
Files for Molecular Dynamics Trajectory and Homology Models.